In vitro inhibition of cholinesterases by carbamates--a kinetic study.

نویسندگان

  • Alena Komersová
  • Markéta Masopustová
  • Karel Komers
  • Sárka Stĕpánková
  • Alexandr Cegan
چکیده

Kinetics and mechanism of in vitro hydrolyses of acetylcholine and acetylthiocholine by carbamates were studied in a batch reactor at 25 degrees C, pH 8, and ionic strength of 0.11 M. Every hydrolysis was monitored by 3-4 independent methods. All studied hydrolyses can be described by the model of competitive inhibition with an irreversible step (k3). A table of obtained average values of rate constants and discussion of the resultes are given.

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عنوان ژورنال:
  • Zeitschrift fur Naturforschung. C, Journal of biosciences

دوره 62 3-4  شماره 

صفحات  -

تاریخ انتشار 2007